The presence of heavy metals in food remains an issue of public health concern. The study was therefore designed to determine the heavy metal concentrations in fish (Clariasgariepinus and Tilapia guineensis). The study made use of Ozoro and Kwale in Delta State, Nigeria. A laboratory based study was adopted. The parameters included, pH, dissolved oxygen (DO), lead, cadmium, chromium, zinc and copper. Descriptive statistics, t-test and ANOVA were used for the data analysis.The mean pH and DO levels in water were 7.20 ± 0.31 and 4.39 ± 2.08 mg/L respectively. The mean concentrations (mg/L) of heavy metals in water were: 0.01±0.01 (cadmium); 0.01 ± 0.01 (chromium); 0.02 ± 0.01 (copper); 0.04±0.01 (zinc); 0.06±0.04 (lead). The heavy metal with the highest concentration found in both fish species was Zinc and the one with the least concentration was Cadmium. The mean concentrations (mg/kg) of heavy metals in cat fish were, 0.73±0.25 (cadmium) ; 4.8 ± 0.34 (chromium) ; 7.51±1.8 (lead) ; 17.62±0.27 (copper) ; 119.22±0.51 (zinc) while those of tilapia fish were, 0.48 ±0.22 (cadmium); 3.57±1.13 (chromium); 7.91 ± 1.69 (lead); 17.37±0.34 (copper) ; 176.82±0.27 (zinc). All heavy metals assessed in fish were above WHO and National guideline limits. The need for adoption and enforcement of appropriate monitoring and management strategies for the protection of the lake is therefore important.