The indispensible position that nucleic acids hold in growth, development, differentiation, heredity, and the sustenance of life itself is self-evident. This chapter presents a basic review of relevant aspects of nucleic acid metabolism and of resultant clinical syndromes in association with pregnancy.These patients have hyperuricemia and thus may have any of the clinical manifestations of gout, including urinary tract stone disease, nephropathy, arthritis, and tophi. Activity of the enzyme hypoxanthine-guanine phosphoribosyl transferase is virtually absent. In this seminar work, we have discussed what nucleic acid, metabolism, and the things that are responsible for metabolism disorder.